西安交大二附院在CAR-T细胞治疗实体瘤领域取得重要进展

QIANHEKANGYUANSHOUTITXIBAO(Chimeric antigen receptor T cells, CAR-T)MIANYIZHILIAOSHILIYONGJIYINGONGCHENGJISHUXIUSHIAIZHENGBINGRENZISHENDETXIBAO,SHIQIHUODEZHONGLIUTEYIXINGSHIBIEJISHASHANGGONGNENG,YISHIXIANYOUXIAOKANGAIZUOYONGDEYIZHONGXINXINGMIANYILIAOFA。JINGUANCAR-TXIBAOZAIXUEYEXITONGEXINGZHONGLIUZHILIAOLINGYUQUDELEYIDINGCHENGJIU,RANERZAIDUOSHUSHITILIUZHONG,YOUYUCUNZAIFUZADEMIANYIYIZHIJIZHI,CAR-TXIBAODEZHILIAOXIAOGUORENGBULIXIANG。LIYONGBAIJIESUDENGMIANYIDIAOJIEXINGXIBAOYINZIRUBAIJIESU-2、BAIJIESU-15DENGKEXIANZHUDETISHENGCAR-TXIBAOZAIZHONGLIUWEIHUANJINGZHONGDEZENGZHI、CUNHUOHESHASHANGXIAOGUO,DANYUCITONGSHI,XIANGGUANXIBAOYINZIXINHAOYIKENENGBUDANGDIJIHUOJITIMIANYIXITONG,SHIGAILIAOFADEANQUANXINGSHOUDAOYANJUNTIAOZHAN。YINCI,JIANGCUSHENGZHANGXINHAOXUANZEXINGDIZUOYONGYUCAR-TXIBAOCHENGLELINGYUNEIDENANTIZHIYI。

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IL-23改造CAR-T细胞机制示意图

CAR-T细胞体内实验数据图

GAIXIANGYANJIUCHENGGUOYI“Interleukin-23 engineering improves CAR T cell function in solid tumors”(BAIJIESU-23XIANGGUANJIYINGAIZAOCUJINCAR TXIBAOZAISHITILIUZHONGDEKANGAIGONGNENG)WEITIFABIAOZAIGUOJIZHUMINGQIKANNature Biotechnology(ZIRANSHENGWUKEJI)SHANG(YINGXIANGYINZI: 31.864)。XIANJIAOTONGDAXUEDIERFUSHUYIYUANZHONGLIUBINGYUANMAXINGCONGBOSHIWEIGAILUNWENDEDIYIZUOZHE,XIANJIAOTONGDAXUEDIERFUSHUYIYUANWEIDIYIZUOZHEDEGONGTONGSHUMINGDANWEI。BEIKALUOLAINADAXUEJIAOTANGSHANFENXIAOLinebergerZONGHEAIZHENGZHONGXINGianpietro DottiJIAOSHOUJIXUYANGBOSHIWEIGONGTONGTONGXUNZUOZHE。

威尼斯官方网站ZHANGSHUQUNJIAOSHOUTUANDUIJINNIANLAIZHUZHONGGUOJIKEYANHEZUO,JIJIYUGUOWAIZHUMINGYANJIUJIGOUJINXINGBOSHIYANJIUSHENGDELIANHEPEIYANG,TIGAOTUANDUIXUESHUSHIYEHEKEYANSHUIPING,TISHENGKEYANNENGLI,CUJINKESHIZHENGTISHUIPINGTISHENG。TUANDUIZHONGZHAOQIANQIANBOSHICENGYUDEZHOUDAXUEMDANDESENAIZHENGZHONGXINFUXIAOZHANGHONGMINGQIJIAOSHOUSHIYANSHIXUEXI,HUODESHIYANSHISUOYOUCHENGYUANDEYIZHIHAOPING,LIUYUANDANGNIANCHENGGONGSHENQINGGUOJIAZIRANKEXUEJIJIN,BINGFABIAOSHUPIANGAOSHUIPINGLUNWEN。

文章链接: http://www.nature.com/articles/s41587-019-0398-2